Biochemistry is structured by unifying themes and organizing principles that are a consequence of genetic control over the shape and function of proteins. Biochemistry investigates the molecular logic of the living state through biomolecule study, energy transformation in cells, chemical reactions in living cells, self-regulation of cell reaction, and the self-replication of living organisms. The text covers: 1) the structures and properties of biomolecules; 2) energy-yielding processes; 3) energy-requiring processes; 4) the replication, transcription, and translation of genetic information. Applications of biochemical knowledge to problems of human health and disease, hormones, metabolism, and DNA are discussed.