The purpose of this series is to provide a resource for concise, detailed reviews of key aspects of the biochemistry of substances of abuse. This text presents pertinent research findings on various effects of drug and alcohol abuse by knowledgeable specialists in this field. Some biochemical changes considered include immunomodulation, altered disease resistance, membrane fluidity and functional modifications, teratogenic effects, and modifications of hormonal regulation and production with major functional consequences. Chapters summarize and evaluate in detail the advances made in understanding the changes in biochemistry or physiology caused by various drugs of abuse. Various drugs of abuse, particularly alcohol and major elicit compounds are emphasized. Information on their effects on nutrition, immunology, biochemistry, metabolism, and pharmacology are included. This text will assist the researcher, clinician and student in comprehending the complex changes caused by the direct and indirect effects of single drugs at the cellular level.