This text of critical care is updated and expanded to reflect the current, clinically relevant information. Conveniently compiled under one cover are the views of those authorities who have contributed to the science and art of caring for critically ill patients. It covers the molecular, cellular, physiologic, clinical, ethical and service-delivery aspects of critical care medicine. This revised edition includes a new section on renal/nephrology, as well as new chapters on heat stroke, hypothermia, transfusion therapy, trauma care of the elderly, mediators of multi-organ failure in sepsis, and gene therapy.