Protein degradation is a major component in cellular metabolism, regulating numerous cell functions, such as the removal of misfolded proteins, growth and cell division, DNA repair, the immune response and the stress response to emergency conditions. This third volume in the series discusses the role of ubiquitin-mediated protein breakdown in cellular regulation and physiology. Drawing on the combined knowledge of the world's leading protein degradation experts, this handy reference includes information on deubiquitylating enzymes tyrosine kinase receptors the COP9/signalosome complex regulation of the NFKB system ubiquitin in transcription, DNA monitoring and repair, and peroxisomes endocytosis and membrane trafficking the ubiquitin-proteasome system in plants and muscle development. Required reading for molecular biologists, cell biologists and physiologists with an interest in the topic.