Set in New York during the Great Depression, Miss Lonelyhearts concerns a nameless man assigned to produce a newspaper advice column--but as time passes he begins to break under the endless misery of those who write in, begging him for advice. Unable to find answers, and with his shaky Christianity ridiculed to razor-edged shards by his poisonous editor, he tumbles into alcoholism and a madness fueled by his own spiritual emptiness.