The most comprehensive and up-to-date review of mammalian and human physiology. Examples from clinical medicine integrated throughout each chapter connect science with practice and illuminate important physiologic concepts. New and expanded coverage of vascular smooth muscle, gene expression, genetic basis of various diseases, obesity, regulation of insulin secretion, dyslexia, circadian rhythms, exercise tolerance, and more. Self-study section with 630 multiple choice questions - ideal for self-assessment and USMLE Step 1 review. More than 700 attractive and informative illustrations. Currently translated into 18 languages and endorsed by students and instructors around the world. Book jacket.