Inventor Flint Lockwood thought he saved the world when he destroyed his machine that turned water into food causing cheeseburger rain and spaghetti tornadoes. But Flint soon learns that his invention survived and is now creating food-animals. Flint and his friends embark on a dangerously delicious mission to battle hungry tacodiles, shrimpanzees, hippotatomuses, cheespiders and other foodimals to save the world again!