Fai clic su di un'immagine per andare a Google Ricerca Libri.
Sto caricando le informazioni... JAK-STAT Signaling in Diseasesdi Ritobrata Goswami
Nessuno Sto caricando le informazioni...
Iscriviti per consentire a LibraryThing di scoprire se ti piacerà questo libro. Attualmente non vi sono conversazioni su questo libro. Nessuna recensione nessuna recensione | aggiungi una recensione
JAK-STAT pathway is one of the few signal transduction pathways that transduce signals involved in multiple homeostatic biological processes including cell differentiation and proliferation, cell death, hematopoiesis and immune responses. JAK-STAT is an elegant pathway that is relatively simple and evolutionary conserved as gene expression is regulated by external parameters. Activated by growth factors or cytokines, this signal transduction cascade regulates the transcription of genes at the nucleus. Mutations and polymorphisms in JAK-STAT pathway are associated with inflammatory diseases and cancers that could impede regular homeostasis. Features: Details activation and microRNA-mediated regulation of JAK-STAT pathway Provides exclusive information about the association of the pathway in various diseases including allergic inflammation, neuro-inflammatory disorder, atopic dermatitis hematopoietic malignancies, cardiovascular disorder, renal disorder, immunodeficiency, liver fibrosis, diabetes and obesity that affect individuals across the globe Clinical relevance of the signaling cascade has been discussed in context of novel class of therapeutics that targets this pathway. An overview of JAK-STAT signaling pathway and the structure-function relationship of different domains of the cascade are discussed. This book provides detailed information on various diseases that are associated with JAK-STAT pathway. It will act as a very good reference book for basic science researchers, academicians, industry professionals involved in translational research leading to product development. This book will excite future professionals towards better understanding of the regulation of this pathway, its association with other signaling cascades to design novel therapeutics. Non sono state trovate descrizioni di biblioteche |
Discussioni correntiNessuno
Google Books — Sto caricando le informazioni... GeneriSistema Decimale Melvil (DDC)616.07Technology Medicine and health Diseases Pathology; Diseases; Treatment PathologyClassificazione LCVotoMedia: Nessun voto.Sei tu?Diventa un autore di LibraryThing. |