Intergalactic plumber Cardamon Webb returns to Warrensberg, Minnesota, to enlist the help of 14-year-old Wilkin Delgado and tug-o-war champion Alice Jane Zelinski to save the universe. (Again.) Apparently, all the fresh water in the universe is drying up and they need to get to the Source to turn it back on. Wilkin and Alice Jane--together with a talking puffin, a glamorous Ergonomic and Fiscal Engineer and a pesky bug--journey to the Inside of the universe, take a balloon fish taxi to the Other side, visit the abandoned metropolis of Pago City, discuss expensive handbags, mindfully follow the path of the plumber's pilgrimage, battle deadly diseases, decipher the text of an ancient prophecy, repel ferocious attacks by Wibgees and Leeblexes, and try to meet the All and Everything and save the universe.